Not holding my breath for any male trans to compete in a male sport; then after winning, pull a Greta Thunberg sized PR stunt to sell his “I Am Woman! Watch Me Roar!” as some “Woke-Rocky” cinema waiting to happen.

Introducing chemical changes to a body does not ultimately change the body. In the same way you can breed a dog to change certain characteristics it does not make the dog a completely different animal. It is in the genetic make up of the body that is still there that proves the fact that man can not re-make nature.

Sorry, I can't consider the premise is valid when it is not true. There are too many variables that come into play much more than hormones. The difference between the male and female brain is a good place to start.

After puberty, even with hormone therapy, the body retains the skeletal and muscular configuration of their genetic sex. Male and female have differently shaped pelvis and the angle of the thigh bone to the knees is different, which causes a difference in how the muscles and tendons attach to the bones and cause a difference in the forces of the muscles on the legs. Genetic males usually have larger, denser bones and muscles than most genetic females. The gonads (sex glands) and other glands will continue to excrete hormones, even if countering hormones are given. So, no, the genetic male will have testosterone plus estrogen; the genetic female's body will produce estrogen, thus making them different chemically.

I simplify this discussion now to two categories: “with penis” and “without penis”.

Forget discussions about biology. They go nowhere because progressives have successfully deconstructed words like “gender”, “male” and “female”, rendering them meaningless.

Avoid the rabbit hole going forward: divide bathrooms, prisons, shelters, and sports by two new categories: one for those “with penis”, and a second for those “without penis.”

Progressives don’t know how to deal with simplicity.

Lets assume this is a possibility, there would have to be accurate inexpensive methods of measuring each and every chemical responsible for gender differences and the level of them, and the level of them in relation to other chemicals. So from here lets assume it is possible which it may be if so inform me, a problem arises with the way sex hormones behave in that they are hardly consistent, and more so with females than males (as in there is massive fluctuation moment to moment). This would need to be accounted for in the measurement process, an perhaps measurements would have to occur every day until the moment the competition takes place. Another variable I can imagine is this, men on the lower end of the male distribution for physical ability are still on another level to that of women on the end of the female distribution, but it depends on what characterizes and low and if for a woman is average for a man etc. This isn't the variable I initially intended on writing, that is on bone structure and density, no matter how you cut it a temperamentally disagreeable woman in a fighting competition against a trans woman who's got higher bone density won't last if skills are matched, his strikes will hit with more force, and she won't handle them as long as he/she could. However if the goal is to implement a more accurate method of classing individuals to minimize disparity in biological advantages this might be worth pursuing. Though I don't have any ideas on how this would be done.

Why assume that a false premise is valid?

Might be a good start...